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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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In conclusion, top TiO2 factories play a crucial role in meeting the global demand for high-quality titanium dioxide products. Companies like DuPont, Kronos, Tronox, and Tayca are leading the way with their superior quality products and innovative technology, making them top choices for manufacturers seeking top-quality TiO2 pigments. By investing in research and development and adopting sustainable practices, these top TiO2 factories continue to set new standards for quality and performance in the industry, driving innovation and growth in the global TiO2 market.

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